Diclofenac Sodium Extended-Release Tablets usually start to work in about 1 to 2 hours after taking them. The speed of onset of action depends mainly on the dose, the duration of administration and the ability to tolerate pain. 1. Dose: If the patient takes a higher dose, the onset of action may be faster. Patients taking a small dose, the onset of action time may be slower, the specific dose of drugs need to follow the doctor’s instructions. Clinically, diclofenac sodium extended-release tablets usually start to work in about 1 to 2 hours after taking. 2. Taking time: patients take on an empty stomach, the effect is faster, while taking after meals, the effect is relatively slower. However, clinically, it is generally recommended that patients take it after meals, because the drug will produce a very large stimulation of the mucous membrane of the gastrointestinal tract. 3. The ability to tolerate pain: the patient’s ability to tolerate pain is relatively strong, take a smaller dose, take a shorter period of time, can play a significant pain effect, and vice versa will be prolonged. Allergy to the product, coronary artery bypass grafting surgery, the application of non-steroidal anti-inflammatory drugs after the occurrence of gastrointestinal bleeding or history of perforation and other people are prohibited to take. Some patients may experience side effects such as headache and dizziness, diarrhea and rash after taking it. CAUTION: Avoid combining the drug with other NSAIDs, including selective COX-2 inhibitors. Adverse effects can be minimized by using the lowest effective dose for the shortest therapeutic time as needed to control symptoms. Diclofenac sodium extended-release tablets should be taken under medical supervision.