If one parent has blood type A and the other parent has blood type B, the child may have blood type A, B, AB, or O. Care should be taken to avoid hemolysis if the mother’s blood type does not match that of the fetus. The genotype of blood type A may be AA or AO, and the genotype of blood type B may be BB or BO. Therefore, the blood genotype of the child may be AO, BO, AB, OO, which may manifest as blood type A, B, AB, O. The blood type of the newborn can be determined by the coagulation process. The blood type of the newborn can be tested by agglutination test. It is important to note that if the mother’s and fetus’ blood types do not match, there is a definite possibility of neonatal hemolysis, manifested by jaundice and anemia, which can be intervened with phototherapy, and if there is a combination of bilirubin encephalopathy, it can be treated by transfusion of plasma or albumin, as appropriate, after evaluation by a clinician.