Hand blisters are usually caused by excessive friction, and treatment usually includes reducing the source of friction and localized treatment such as picking the blisters and then disinfecting them with iodine povidone. Hand blisters belong to friction dermatitis, which are blisters formed by the exudation of subcutaneous tissue caused by prolonged friction at a certain location on the hand. In order to cure the blisters completely, it is necessary to get rid of the working and living environment that causes friction dermatitis. When blisters appear, they should be opened with a sterile tool and treated with an external anti-inflammatory treatment. Commonly used external anti-inflammatory drops are povidone-iodine, and then appropriate application of erythromycin ointment or clindamycin ointment to prevent infection. If the blisters are large in size, go to the surgery for proper bandaging, on the one hand, to protect the tissues of friction dermatitis from further injury, and on the other hand, to protect the wound from re-infection. If the blisters are serious, or the symptoms persist and do not improve, you should go to the hospital for treatment.