Symptoms of advanced diffuse large b-cell lymphoma gcb subtype include painless lymph node enlargement, organ-specific symptoms and systemic wasting symptoms. 1. Painless lymph node enlargement: localized progressive painless lymph node enlargement, tough texture, poor relative mobility, and some lymph nodes will be fused into clusters. In the advanced stage of the disease, generalized lymph node enlargement may occur, which is more serious. 2. Organ-specific symptoms: for example, if lymphoma invades the lungs, it will manifest respiratory symptoms such as dyspnea, cough, sputum, etc.; if it invades the abdominal cavity, there will be abdominal pain, abdominal masses, ascites and other related symptoms; the skin and mucous membranes will also have localized itchiness and rashes and other symptoms. 3. Systemic consumptive symptoms: diffuse large b-cell lymphoma has certain malignant aggressiveness, and the cancer cells will spread to the whole body, and the patients will have fever, emaciation, poor physical strength and other symptoms. In addition, patients with advanced stage will have total blood cell reduction, which will cause serious bleeding, infection and other complications, and easily endanger life due to progressive aggravation of complications. It is recommended that patients go to the hospital for regular review, take into account the development of the disease, and actively treat the disease under the guidance of the physician in order to prolong the survival of patients in advanced stages.