Big toe pain may be a manifestation of gouty arthritis, traumatic arthritis, infectious arthritis, rheumatoid arthritis and other diseases, and it needs to be judged whether it is caused by gout through the methods of history and symptoms, uric acid level, joint fluid examination and imaging examination. 1. History of symptoms: Gout-induced big toe pain starts suddenly at midnight or early in the morning, peaks in a few hours, with redness, swelling, heat and pain in the affected joints, mostly relieved within 2 weeks, and the skin at the affected joints is flaky after the redness and swelling subside. Gouty big toe pain mostly has a history of hyperuricemia, may have a recent high purine diet, may appear gouty stone, no history of trauma, history of infection. 2. Uric acid level: high level of uric acid in blood and urine is an important way to determine gout-induced big toe pain, and can be used as a routine auxiliary diagnostic test. Other causes of big toe pain are usually not accompanied by increased uric acid levels. 3. Joint fluid examination: after joint puncture, analyzing whether the joint fluid contains urate crystals is the best examination to diagnose gout, infectious arthritis can often be cultured to find the causative organisms, while rheumatoid arthritis often contains autoantibodies. 4. Imaging examination: joint fluid examination can not confirm the diagnosis and clinical manifestations of atypical gout suspected patients, can be X-ray or ultrasound, gout typical manifestations can assist in the diagnosis, and other diseases for differentiation. To summarize, there are many causes of big toe pain, if there is big toe pain, it is recommended to go to the hospital in time to improve the relevant examination to clarify the cause of the disease and receive targeted treatment.