There are many reasons why the mouth speaks crookedly, which are commonly caused by facial neuritis and cerebrovascular disease, and the treatments include medication and surgery. 1. Facial neuritis: also known as facial paralysis. Crooked mouth may be peripheral facial paralysis or central facial paralysis. Treatment includes medication and surgery. (1) Drug treatment: glucocorticoid hormone can be applied to reduce inflammatory edema; oral acyclovir and other antiviral drugs; taking drugs that nourish the nerves, such as vitamin B1, vitamin B12 and so on. (2) Surgical treatment: such as facial nerve decompression surgery, which can relieve the compressed facial nerve. 2. Cerebrovascular disease: such as cerebral infarction, cerebral hemorrhage, etc., can also cause the patient’s mouth to speak crookedly. For patients with mild symptoms, conservative treatment with medication can be taken, such as thrombolytic drugs (alteplase) for cerebral infarction and hemostatic drugs (tranexamic acid, tranexamic acid, etc.) for cerebral hemorrhage. Surgery can be used if necessary. In addition to the above reasons, oral diseases such as misalignment of the upper and lower jaws can also cause the above symptoms. If the mouth is not congenitally crooked but the symptoms occur suddenly, patients are advised to go to the hospital as soon as possible to find out the cause of the disease and undergo formal examination, so as not to miss the best time for treatment. Medications should be taken under the guidance of a physician.