Skin melanin deposits can be a symptom of post-inflammatory hyperpigmentation, pigmentation spots, acanthosis nigricans, and other conditions. Patients can remove it through general treatment, medication and physical therapy. 1. Post-inflammatory hyperpigmentation: Post-inflammatory hyperpigmentation refers to skin pigmentation secondary to acute or chronic inflammatory processes. Patients need to pay attention to avoid sun exposure and various inflammatory stimuli in daily life. Hydroquinone cream, vitamin A acid ointment, azelaic acid ointment and other topical drugs can be used externally, and vitamin C and other drugs can be taken orally if necessary. 2. Pigmented spots: pigmented spots are hyperpigmented skin diseases in which the local skin appears patches, spots and different colors with the surrounding skin. Patients need strict sun protection and healthy dietary habits in daily life. Localized lesions can be used externally with tretinoin cream, retinoic acid ointment and other drugs, or oral vitamin C, tranexamic acid and other drugs. Those who are ineffective in drug treatment can be removed by laser, freezing and other physical treatments. 3. Acanthosis nigricans: Acanthosis nigricans is a skin disease characterized by symmetrically distributed hyperpigmentation and velvety thickening. Patients with acanthosis nigricans need to remove the cause of the disease. For example, obese patients can lose weight through healthy diet and regular exercise. Patients with unknown etiology can use topical medications such as carboplatinol ointment and salicylic acid ointment. If necessary, they can be removed by physical therapy such as carbon dioxide laser. It should be noted that all the above drugs should be used under the guidance of a specialist. Patients with skin melanin precipitation should go to regular hospitals in time to find out the cause of the disease and treat the symptoms.