Breath-holding in sleep may be related to functional disorders, or it may be caused by central sleep apnea syndrome, throat disorders, cardiac disorders, and so on. 1. Functional diseases: commonly seen in neurosis, autonomic dysfunction and other diseases, can lead to sleep breathlessness. For example, autonomic dysfunction can lead to neurological disorders and dysregulation of the autonomic nervous system, which may cause breathlessness, accompanied by panic, dizziness and other symptoms. 2. Central sleep apnea syndrome: usually caused by brain infection, traumatic brain injury, myelitis, viral encephalitis and other diseases of the central system, the patient’s main manifestations are insufficient ventilation, apnea, respiratory interruptions, which leads to sleep breathlessness, and may also be accompanied by fatigue and nervousness, excessive drowsiness and other symptoms. 3. Diseases of the pharynx and throat: commonly seen in enlarged tonsils, adenoid hypertrophy, sinusitis and other diseases, which may cause patients to breathe poorly during sleep, resulting in breath-holding during sleep. 4. Diseases of the heart: such as coronary heart disease, arrhythmia, angina pectoris and other diseases, may lead to panic attacks, shortness of breath and other uncomfortable symptoms while sleeping, which may make the patient sleep feeling breathless. Breathlessness in sleep may also be caused by other reasons, it is recommended to consult a doctor as soon as possible, after clarifying the causes, the doctor will guide the treatment and adjustment.