Dry syndrome may cause nephrotic syndrome. Dry syndrome is a diffuse connective tissue disease characterized by invasion of exocrine glands such as lacrimal and salivary glands, abnormal proliferation of B-lymphocytes, and infiltration of tissue lymphocytes. Clinically, it mainly manifests as dry keratoconjunctivitis and oral dryness, and can also involve internal organs. About 30% to 50% of patients have renal damage, which mainly involves the distal renal tubules, and proximal renal tubular damage is less common. Glomerular damage is more obvious in some patients. Therefore, dry syndrome may cause nephrotic syndrome. Patients with dry syndrome are advised to go to regular hospitals in time and standardize the treatment under the guidance of doctors, so as not to delay the condition and cause adverse effects.