Usually, chronic atrophic gastritis C2 does not require long-term medication. Due to individual differences in the situation, it can not be generalized. Chronic atrophic gastritis C2 belongs to mild to moderate atrophic gastritis, and the main symptoms include epigastric discomfort, belching, and feeling of fullness. After clarifying the diagnosis of chronic atrophic gastritis, it is necessary to find out whether it is accompanied by Helicobacter pylori infection. 1. If the patient is infected with H. pylori, it is necessary to carry out the treatment of eradicating H. pylori before treating chronic atrophic gastritis. Usually, a quadruple regimen is used to treat H. pylori: 1 proton pump inhibitor + 2 antibiotics + 1 bismuth agent, such as omeprazole, amoxicillin, clarithromycin, and bismuth potassium citrate. The course of treatment is 10 to 14 days, please follow the doctor’s instructions for medication. 2. If there is no Helicobacter pylori infection, only symptomatic treatment is needed, such as: drugs to inhibit gastric acid (omeprazole, rabeprazole, etc.), drugs to promote gastric motility (e.g., domperidone, mosapride citrate, etc.), neutralizing gastric acid (magnesium alumina carbonate, etc.), and gastric mucous membrane protectors (bismuth pectin, bismuth potassium citrate tablets, etc.). Please follow the doctor’s instruction for the specific dosage of drugs. It is recommended that patients go to the hospital for relevant examinations in time to clarify the extent of the disease and then give timely treatment.