Roxithromycin than cephalosporin can not absolutely say who is powerful. The therapeutic effect of the drug is related to the patient’s physical condition, the disease-causing bacteria, the severity of the disease and other factors, directly saying which drug is more powerful is one-sided, and can not directly make conclusions. For example, if the patient is allergic to cephalosporins, the treatment effect of roxithromycin will be better; when the patient needs empirical anti-infection treatment, the choice of broad-spectrum third-generation cephalosporins is more effective. 1. Roxithromycin exerts antibacterial effect by inhibiting protein synthesis, and its antibacterial spectrum includes Gram-positive cocci, Gram-negative cocci, Haemophilus influenzae, pertussis bacilli, Legionella pneumophila, Mycoplasma pneumoniae, Chlamydia, and anaerobic digestive cocci. Gastrointestinal reactions are common after the use of the drug, can also cause hepatotoxicity, ototoxicity, Q-T interval prolongation and other adverse reactions. It is forbidden for those who are allergic to this product. 2. Cephalosporins play an antibacterial role by inhibiting the synthesis of cell wall, divided into four generations, the antibacterial spectrum is gradually increasing, nephrotoxicity is gradually decreasing, and from the third generation onwards, it is also effective against β-lactam-resistant bacteria. The drug can lead to allergic reactions, and in severe cases, can lead to shock. Do not drink alcohol after using the drug, it will trigger disulfiram-like reaction. Note that hypersensitivity to the product and a history of penicillin shock are contraindicated. Patients should use the drug under the guidance of a medical professional, do not use the drug without authorization.