There is no such thing as which three symptoms indicate that the cancer has spread. There are many symptoms that may appear when the cancer has spread, which are related to the site of cancer metastasis. The main ways of cancer metastasis are trans-lymph node metastasis and trans-bloodway metastasis. Trans-lymph node metastasis may appear as enlarged lymph nodes, which can be touched in superficial parts of the patient’s neck, armpit, groin and other superficial parts of the body. If the cancer metastasizes to distant organs, uncomfortable symptoms may also appear. For example, if the cancer metastasizes to the brain, dizziness, headache and other symptoms may appear, and when the tumor enlarges and causes the intracranial pressure to rise, the symptom of projectile vomiting may appear. When cancer metastasizes to the lungs, symptoms such as cough, chest tightness and chest pain can occur; when cancer metastasizes to the liver, symptoms such as loss of appetite and epigastric pain can occur; when cancer metastasizes to the bone tissues, symptoms such as bone pain or even pathological fracture can occur.