There is no simplest way to confirm the diagnosis of intracranial infections, which requires a combination of questioning, physical examination, laboratory tests, and imaging tests. Among them, positive cerebrospinal fluid culture is the gold standard for diagnosis. 1. Consultation: focus on the presence of adjacent or systemic infections prior to the onset of the disease, possible foci of infection, and pre-symptoms, such as cough, sore throat, nausea, and vomiting. 2. Physical examination: Physical examination is mainly to detect the patient’s physical reaction, if the patient has a disease, in the process of examination can be found in most cases of meningeal irritation, such as cervical rigidity and other symptoms. This examination is relatively simple, but requires high experience of doctors. 3. Laboratory tests: Laboratory tests can also detect intracranial infections. This test includes routine blood and cerebrospinal fluid tests, as well as blood and cerebrospinal fluid cultures. If neutrophils, leukocytes, increased cerebrospinal fluid pressure, and positive cerebrospinal fluid culture appear during the examination, intracranial infection may exist. 4. Imaging examination: Imaging examination is a commonly used clinical diagnostic method, in which CT examination and magnetic resonance imaging can also be used to determine the location and characteristics of intracranial infection brain lesions. It is recommended that patients with intracranial infections choose the most appropriate examination measures according to the guidance of specialized doctors.