Pimples medically known as acne, forehead acne is a follicular sebaceous glands of chronic inflammatory skin disease, topical drugs can be used adapalene, tazarotene, retinoic acid ointment and so on. 1. Adapalene: This product is suitable for the skin treatment of acne vulgaris with pimples, papules and pustules as the main manifestations. It can also be used to treat acne on the face, chest and back. The main adverse reaction that may occur with this medication is skin irritation, which may be reversible after reducing the number of doses or discontinuing the medication. It is contraindicated in people who are allergic to adapalene or any of the ingredients in the gel excipient. 2. Retinoic Acid Ointment: It may be used as a solo – line agent for mild acne, as a combination agent for moderate acne, and as the first choice for maintenance therapy for acne. Topical application of this product may cause skin irritation such as burning, erythema and flaking. Use may be intermittent or suspended as directed by the physician. Contraindicated in women in the first trimester of pregnancy. Acute or subacute dermatitis, eczema skin disease patients are prohibited. 3. Tazarotene: belongs to the third generation of retinoic acid drugs, with better tolerability, usually as the first-line choice. The main adverse reactions after the use of the drug are flaking, dry skin, erythema, burning, itching, skin irritation, pain and tingling in a small number of patients (1% to 5%). It is contraindicated in pregnant women, lactating women and women with recent childbearing intentions. All of the above medications should be used in accordance with medical advice. Patients are advised to seek timely medical attention and choose medication for treatment under the guidance of a doctor, and not to use medication without authorization, so as not to cause adverse reactions.