Methylcobalamin and Epalrestat combined medication generally need to take at least 3 months, it is recommended to follow the doctor’s instructions to use the drug, do not stop the drug, if side effects occur, it is recommended to consult a doctor as soon as possible, under the guidance of a professional physician to adjust the use of medication. Mecobalamin is an active vitamin B12 preparation, Epastar belongs to the inhibition of aldose reductase activity drugs, the two belong to different principles of diabetic peripheral neuropathy drugs, with the repair of damaged nerve cells, to improve the role of the symptoms of patients with diabetic neuropathy, in the clinic, the two are often combined, due to the slow efficacy of the neuropathy, the course of treatment is generally at least 3 months. In addition, the severity of diabetic neuropathy and blood glucose levels are closely related, so controlling blood glucose and blood pressure is also very important for treatment. The combination of methylcobalamin and epalrestat should be taken for at least 3 months, and the treatment should be individualized, so it is recommended to ask the treating doctor about the specific course of treatment.