Domestic targeted drugs for hepatocellular carcinoma mainly include donafenib and apatinib. 1. Donafinil is Donafinil Tosylate Tablets: it is a deuterated compound of Sorafinil, and its mechanism of action is the same as that of Sorafinil, which is a multikinase inhibitor. It can inhibit the proliferation of various human tumor cells in vitro. Donafinil is indicated for patients with unresectable hepatocellular carcinoma who have not previously received systemic systemic therapy. 2. Apatinib i.e. Apatinib Mesylate Tablets: Apatinib is a small molecule vascular endothelial growth factor receptor 2 (VEGFR-2) tyrosine kinase inhibitor, which can inhibit tumor angiogenesis and may inhibit tumor growth. Apatinib is indicated for patients with advanced gastric adenocarcinoma or adenocarcinoma of the gastro-esophageal junction who have progressed or relapsed after receiving at least 2 prior systemic chemotherapies, and patients with advanced hepatocellular carcinoma who have failed or are intolerable after receiving at least one prior line of systemic therapy. It is recommended to go to regular hospitals to evaluate the condition, follow the doctor’s instructions to cooperate with the treatment, and choose the appropriate treatment plan to avoid delaying the condition. Please strictly follow the doctor’s prescription for drug treatment and do not use drugs by yourself.