No response after taking orlistat capsules, there may be drugs itself, personal constitution, dosage, medication time and other aspects of the reason, need to be analyzed. 1. The drug itself: when taking orlistat capsules have quality problems or have passed the expiration date, it will affect its pharmacological effect, which may lead to the emergence of the situation after taking the ineffective. 2. Individual constitution: If the user of the drug on orlistat capsules of low sensitivity or have developed drug resistance, or does not meet the indications of the drug (i.e., overweight or obesity), may lead to ineffective after taking. 3. Dosage: the recommended therapeutic dose of orlistat capsules is 1 capsule / times, 3 times / day (specifications 0.12g / capsule), at mealtime or 1 hour after meals orally, if you do not regulate the use of the drug in accordance with the requirements of the above, may lead to ineffective. 4. Dosing time: drugs need a certain time to take effect, research suggests that the effect of orlistat capsules can generally be seen 24 to 48 hours after the administration of the drug, not up to the time of the drug may not be observed for the time being the effect. Orlistat is a lipase inhibitor, if dietary fat content is low, orlistat is also ineffective. It should also be noted that orlistat capsules are contraindicated in people who are allergic to it, children, pregnant or breastfeeding women, and people with chronic malabsorption syndrome, organic obesity, etc. Adverse reactions such as increased gastrointestinal gas and steatorrhea may also occur during the process of using the drug.