Waking up at 3 or 4 a.m. and sweating should alert you to diseases such as tuberculosis, and also menopausal women can sweat at night due to hormone level disorders. After the organism is infected with Mycobacterium tuberculosis through the respiratory tract, the patient is infected with tuberculosis, which can be manifested in different clinical manifestations such as low-grade fever, cough, sputum, night sweats, fatigue and weight loss. Night sweating refers to the manifestation of abnormal sweating during sleep, but the sweating stops after waking up. Perimenopausal syndrome occurs in women before and after menopause due to a decrease in the secretion of sex hormones. Due to the decrease in estrogen level, women’s vasodilatory function is unstable, and hot flashes, stress or night time are prone to recurring facial, chest and other parts of the skin, such as fever, sweating and other manifestations. The presence of frequent sweating when waking up at night suggests prompt medical attention, tuberculin test or other relevant examinations to identify the cause, and if necessary, follow the doctor’s instructions for treatment.