Cardia iic lesion, i.e., IIc lesion, is an early gastric cancer that occurs in the cardia area of the stomach, and is superficially and slightly concave in microscopic examination. Gastric cancer refers to malignant tumors originated from epithelial cells of gastric mucosa, and the stomach can be divided into three parts: cardia, gastric body and gastric sinus. Early gastric cancer refers to the lesion is limited and its depth does not exceed the submucosal layer, and there is no obvious symptom and sign of early gastric cancer, so gastroscopy is the most reliable diagnosis means at present. Gastroscopy is the most reliable diagnostic tool nowadays. Under gastroscopy, early gastric cancer can be categorized into three types: Ⅰ, Ⅱ, Ⅲ, which represent bulging, flat, and sunken, respectively, while type Ⅱ can be subdivided into three subtypes: Ⅱa superficial bulging, Ⅱb superficial flat, and Ⅱc superficial sunken, so cardia Ⅱc lesion means early gastric cancer occurring in the cardia area of the stomach, which is superficially and slightly sunken under gastroscopy. After discovering cardia IIc lesion, it is necessary to go to the hospital in time and treat it according to the doctor’s prescription in order to slow down the progression of the disease.