Hand numbness and weakness can be caused by cervical spondylosis, multiple peripheral neuritis, cerebral infarction, Guillain-Barre syndrome and other diseases, which need to be treated with medication, life interventions, surgery and other treatments. 1. Hand numbness and weakness caused by cervical spondylosis is mainly caused by compression of the nerve root, and can be prescribed to take celecoxib, diclofenac and other medications to alleviate the pain, and if necessary, need to undergo surgical resection of the intervertebral disc treatment. At the same time, patients need to correct bad posture, pay attention to local warmth. 2. Hand numbness and weakness caused by multiple peripheral neuritis may be related to poisoning, infection and other factors, can follow the doctor’s instructions to take vitamin B1, methylcobalamin and other drugs to nourish the nerves, so as to alleviate the symptoms. 3. Hand numbness and weakness caused by cerebral infarction may be related to infection, immunity and other factors, which may be accompanied by nausea, dizziness, hemiplegia and other symptoms, and may be treated with anti-platelet drugs such as aspirin as prescribed by the doctor, and at the same time, should maintain a regular work and rest schedule, and control the blood pressure, blood fat and so on. 4. The hand numbness and weakness caused by Guillain-Barre syndrome is mainly related to autoimmune injury, which can be accompanied by ataxia and other movement disorder symptoms, and can be treated with macrolide antibiotics such as roxithromycin and glucocorticosteroids such as dexamethasone as prescribed by the doctor. There are many causes of hand numbness and weakness, and it is recommended that people who have not been relieved or even aggravated for a long time should consult a doctor in time to find out the cause of the problem and then treat the cause of the problem, so as to avoid delaying the condition.