Oral and lip herpes may be caused by herpes simplex virus infection. In addition, factors such as decreased resistance of the patient, fever or cold, hormonal changes in the body, overexertion, and stress may increase the risk of the disease. Herpes orofacialis is a skin disease caused by herpes simplex virus infection and is characterized by clusters of small blisters on the lips or surrounding skin. The herpes virus can be transmitted through direct contact with blister exudates, as well as through kissing or contact with contaminated utensils, razors, and towels. Patients with primary herpes orofacialis may have symptoms such as localized flushing of the affected area with burning, pain or itching sensation, while patients with recurrent herpes orofacialis may have symptoms such as fever, malaise, anorexia, sore throat, swollen lymph nodes, etc., and pinhead-sized blisters may appear as the disease progresses. It is recommended that patients seek timely medical examination, targeted treatment, maintain a light diet in life, pay attention to vitamin supplementation, prohibit the consumption of spicy stimulation, too cold and too hot food, etc., at the same time, patients should also avoid sharing towels, lip balm and cutlery and other items.