The pain in the corner of the eye when pressed may be caused by granuloma, scleritis and glaucoma. 1. Granuloma: If the patient’s corner of the eye is accompanied by localized cysts, it may be caused by granuloma, which can be treated with antibiotics as prescribed by the doctor, such as ofloxacin eye drops, tobramycin eye drops and so on. 2. Scleritis: if the patient is accompanied by the symptom of redness of the white of the eye, it may be caused by scleritis, which can be treated with anti-inflammatory drugs, such as methylprednisolone and so on as prescribed by the doctor. 3. Glaucoma: If the patient suffers from closed-angle glaucoma, there may be a sudden rise in intraocular pressure, resulting in pain when the corner of the eye is pressed. Patients can follow the doctor’s instructions to use mannitol injection, brinzolamide eye drops and other drugs for treatment. There are many reasons that cause pain when the corner of the eye is pressed, it is recommended that patients find this symptom and go to the hospital in time for a detailed examination, to clarify the cause of the disease, targeted treatment.