Numbness and pain in the big toe may be caused by insufficient blood supply to the foot due to wearing small shoes, and also need to consider lumbar disc herniation, diabetic neuropathy, thromboembolic vasculitis, peripheral neuritis and so on. 1. Lumbar disc herniation: lumbar hyperplasia, herniated nucleus pulposus and other compression of nerves can be radiated to the lower limbs, resulting in pain and numbness, which can be clearly diagnosed by lumbar spine MRI. 2. Diabetic neuropathy: complications caused by diabetes mellitus, such as neuropathy, can appear numbness and pain in the lower limbs, coldness, ants sensation and other symptoms, and can be treated with gabapentin or pregabalin under the guidance of the doctor. 3. Thromboembolic vasculitis: the occlusion of blood vessels in the lower limbs causes poor blood supply to the lower limbs, which can cause numbness and pain in the toes and coldness in the limbs, and can be treated with sodium beclomethasone to alleviate the symptoms. 4. Peripheral neuritis: due to vitamin deficiency, infection or poisoning, etc., it can cause sensory impairment at the end of the limb. Big toe numbness and pain is recommended to go to the hospital in time, to clarify the cause of the disease, for the cause of the treatment, and under the guidance of the doctor to use the above drugs.