Uneven density of rib bone is an imaging description, which means that the local bone density of rib bone is increased or decreased, which is common in osteoporosis, trauma, inflammation, tumor and other diseases. 1. Osteoporosis: Osteoporosis occurs in the middle-aged and elderly people, and is related to age, estrogen level, disease and other factors, which may result in sparse local trabeculae, and then show uneven density of the rib bone. 2. Trauma: If the ribs are traumatized or have old injuries, such as a rib fracture, osteophytes will easily appear at the broken end of the fracture, which will cause uneven bone density of the ribs. 3. Inflammation: Inflammatory reaction of rib due to various reasons such as injury and infection will also cause uneven density of rib bone. 4. Tumor: If bone tumor occurs in the ribs, it may damage the normal bones and cause hyperplasia or necrosis in different parts, which may also cause uneven bone density of ribs. The uneven density of rib bone is only an imaging manifestation, and there are many possible causes, which may be related to local cysts, ischemic necrosis, etc. Clinicians need to combine all the information to make a comprehensive judgment and clarify the etiology of the disease.