Non-atrophic gastritis with focal atrophy and hyperplasia requires treatment. Non-atrophic gastritis is a condition in which the gastric mucosa is infiltrated mainly by lymphocytes and plasma cells and may be accompanied by bile reflux and erosion, which may be manifested as epigastric pain, abdominal distension, postprandial fullness, loss of appetite, belching (hiccups), and acid reflux. Focal atrophy indicates localized mucosal atrophy, vascularization, etc. If atrophy develops over a long period of time, it may develop into intestinal metaplasia. Hyperplasia may be inflammatory hyperplasia or atypical hyperplasia, which has the risk of malignancy and may develop into gastric cancer if not treated in time. Therefore, non-atrophic gastritis with focal atrophy and hyperplasia needs to be treated actively. Patients with non-atrophic gastritis with focal atrophy and hyperplasia should go to the hospital in time, and need to actively remove the cause of the disease, alleviate the symptoms, and improve the inflammation of the gastric mucosa, so as to avoid adverse effects.