In general, enemas are not harmful to the body, but frequent enemas may cause intestinal flora dysbiosis, intestinal mucosal damage, constipation and other conditions. 1. Intestinal flora imbalance: If the enema is frequent, it may lead to intestinal micro-ecological environment disorders, and bacterial infections may occur. 2. Intestinal mucosal injury: Because enema is an invasive operation, if the patient does not cooperate properly or the technician does not operate properly in the process of enema, it can lead to intestinal mucosal injury, which is easy to cause infections, and in severe cases, intestinal perforation or anal fistula can occur. 3. Constipation: frequent enemas can lead to intestinal peristalsis, so constipation can occur. Enema need to be carried out under the guidance of a physician, daily should develop good habits, intake of adequate vitamins and dietary fiber, drink more water, to maintain a smooth bowel movement.