Mammary gland hyperplasia with overflowing nipples is usually not very serious. Mammary hyperplasia is a physiological process and cannot be diagnosed as a disease. However, nipple overflow is a different condition with many causes, some of which are physiological in nature and do not require special intervention. If the nipple overflow is caused by the use of drugs, due to their side effects, the side effects will gradually decrease as the treatment of the primary disease ends, and there is nothing to worry about in this case. Some patients with pathological causes of nipple overflow should be taken seriously and need to see a specialist for consultation, history taking and careful physical examination, and if necessary, through imaging examinations such as ultrasound to clarify the diagnosis; some patients with pathological causes of nipple overflow need to be clearly diagnosed through surgery and other methods. The combination of mastocytosis and nipple overflow should be treated specifically, but overall it is not too serious and patients do not need to be nervous.