It usually takes years or decades for atrophic gastritis to transform into stomach cancer, which is a long-term chronic disease. Therefore, early treatment of atrophic gastritis can reduce the chance of cancer. Atrophic gastritis refers to the atrophy of the intrinsic glands in the gastric mucosa of the patient, which is usually directly related to the presence of Helicobacter pylori infection. If atrophic gastritis is not treated in time and further intestinal epithelial hyperplasia occurs in the atrophic area, it may lead to cancerous changes and develop into gastric cancer. When treating atrophic gastritis, if H. pylori infection is present, comprehensive anti-H. pylori treatment can be carried out using quadruple therapy (two antibiotics, a proton pump inhibitor, and a bismuth agent), such as amoxicillin, clarithromycin, omeprazole, and bismuth pectin. Early treatment of atrophic gastritis can effectively reduce the chances of gastric cancer, so it is recommended that people with gastric problems should go to the hospital regularly for gastroscopy and early treatment.