Diffuse astrocytic glioma is a type of glial cell tumor from the nervous system of the brain and is an intracranial malignancy. Astrocytic tumors are associated with genetics, radiation, and carcinogens, and are most commonly found in the cerebral hemispheres in adults and in the cerebellar hemispheres in children. The tumor is slow growing and has a long history. Astrocytoma often manifests as epilepsy, headache, vomiting, and if the tumor invades the frontal lobe or corpus callosum, the patient may experience mental disorders and personality changes. Surgery for low-grade astrocytomas is more effective, and there may be hope for complete eradication of cerebellar hemisphere astrocytomas after complete resection. Infiltrating growing cerebral hemisphere astrocytomas are not curable by surgery, and after resection of the tumor a film containing kazacitidine is implanted in the tumor bed tract and gradually released over 2 to 3 weeks. Postoperative radiation therapy and chemotherapy were administered. When patients are examined for diffuse astrocytomas, it is recommended that they be treated directly in the hospital to avoid delays.