Rheumatoid factor 500IU/ml, elevation is more obvious and serious. Therefore, patients are advised to go to the rheumatology department or other related departments for examination and symptomatic treatment. The normal value of rheumatoid factor is between 0 and 20IU/ml, and exceeding this range indicates that the rheumatoid factor is elevated. In many patients with rheumatoid arthritis, the rheumatoid factor reaches 500IU/ml, which is a more serious condition. Rheumatoid factor can also be seen in systemic lupus erythematosus, dry syndrome and other autoimmune diseases; can also be seen in some acute viral infections such as mononucleosis, hepatitis, influenza, etc.; can also be seen in some chronic bacterial infections such as tuberculosis. Patients should pay attention to keep warm in daily life, do not get cold, regular work and rest, do not stay up late and reasonable diet. Eat more food rich in unsaturated fatty acids. It is recommended that patients with positive rheumatoid factor should go to the rheumatology and immunology department or other related departments, and complete the relevant examinations under the guidance of the doctor, so as to clarify the cause of the disease and make early diagnosis and treatment.