Solid nodules in the lungs may be benign or malignant, but the chances of malignancy are less. Solid lung nodules are generally benign conditions that can be infectious or non-infectious. In general, the nature of solid lung nodules over 1 cm can be further clarified by percutaneous cytology and histology. Some solid nodules are highly suspicious for bronchopulmonary carcinoma, and the nature of the solid nodule needs to be clarified by thoracoscopic surgery and intraoperative snap-frozen sections. If pathologic, solid lung nodules larger than 1 cm usually have a higher probability of malignancy. However, if a calcified component is present in the lesion, solid nodules are more likely to be benign tumors, especially in tuberculosis, which tends to be prone to a calcified component. In the case of benign or malignant solid nodules in the lungs, local puncture can be taken first to detect the tissue inside the nodule and check whether tumor cells are present, or the nodule can be directly excised for pathological examination to make a clear diagnosis, and then a treatment plan can be chosen according to the doctor’s guidance.