Aspirin is not recommended to be taken at the same time with other non-steroidal anti-inflammatory drugs, anticoagulants such as heparin, pro-uric acid excretory agents, hormones and methotrexate. 1. Aspirin in combination with other non-steroidal anti-inflammatory drugs will aggravate the adverse effects on the gastrointestinal tract and increase the risk of peptic ulcers and bleeding. When aspirin is used with anticoagulants such as heparin, it greatly increases the risk of bleeding in patients, such as cerebral hemorrhage and gastrointestinal bleeding. 2. Aspirin can cause a decrease in blood concentration when used in combination with uric acid excretory agents. Hormones have the risk of causing the body to bleed, such as aspirin and the combination of bleeding risk will increase. Concomitant use of aspirin with diuretics may result in salicylosis. Concomitant administration with methotrexate may increase methotrexate toxicity. 3. Adverse effects of aspirin include gastrointestinal disturbances such as dyspepsia, gastrointestinal pain, bleeding, hematoma, epistaxis, rash, urticaria, etc. Contraindications include allergy to aspirin and salicylates, asthma to aspirin, acute ulcers of the gastrointestinal tract, severe cardiac, renal, and hepatic failure, combination with methotrexate, and contraindication to use in the second trimester of pregnancy. The use of aspirin is recommended to consult a professional physician, follow the doctor’s instructions, to avoid blindly use their own medication.