Glipizide Controlled-Release Tablets and Metformin can be taken together, but should be combined together as directed by your doctor. Glipizide Controlled Release Tablets are generally used to treat patients with mild to moderate type 2 diabetes. Metformin is indicated for people who are obese and with hyperinsulinemia. The combination of the two drugs is more effective, patients taking these two drugs are recommended to take under the diagnosis and guidance of a doctor, it is not recommended to take medication privately. When patients take metformin, some people will be a little bit of gastrointestinal discomfort, which is a side effect of metformin, it is recommended that metformin can be taken in the meal or after the meal, by taking after the meal can be appropriate to reduce gastrointestinal reactions. It is also not recommended to take Glipizide Controlled-Release Tablets for people with digestive tract stenosis and diarrhea. Glipizide Controlled-Release Tablets and Metformin should be used in strict accordance with medical advice.