Colchicine should not be taken for ulcerative colitis. Ulcerative colitis is not an indication for colchicine. Colchicine is indicated for the treatment and prevention of acute exacerbations of gouty arthritis, while the development of ulcerative colitis is not necessarily associated with the development of gouty arthritis. Application of colchicine during acute attacks of ulcerative colitis can lead to worsening of symptoms. Ulcerative colitis can be characterized by diarrhea, abdominal pain, and mucus-pus-blood stools, and common adverse reactions to colchicine include diarrhea, abdominal pain, nausea, and vomiting. Colchicine is contraindicated in pregnant and lactating women, patients with hepatic or renal insufficiency, and patients with gastrointestinal disorders need to use with caution. As to whether ulcerative colitis patients can use colchicine, it is recommended that patients go to the hospital in a timely manner, and be guided by the doctor according to the condition of the medication.