Whether hepatitis major three yang need treatment, combined with other test results, hepatitis B major three yang patients are generally HBV DNA positive, if accompanied by abnormal liver function or the performance of cirrhosis, it is necessary to give antiviral treatment, antiviral treatment is divided into two categories of programs: First, the injection of interferon. Long-acting interferon is injected once a week; domestic short-acting interferon is injected once every two days for a period of one to two years. This program is more troublesome to operate, there are certain side effects, the efficiency is about 70%-80%, but the course of treatment is fixed, two years can stop the drug. Second, oral nucleoside drugs, the current mainstream drugs are entecavir and tenofovir, are once a day, each time a capsule, but the course of treatment is not fixed, need long-term treatment.