Multiple nodules in the head of pancreas have more causes, which may be inflammatory reaction or tumor manifestation, and should be analyzed according to the accompanying symptoms. 1. Inflammatory reaction: for example, chronic pancreatitis, acute pancreatitis, etc., long-term stimulation by inflammation may form multiple nodules, often accompanied by yellowish color, nausea, vomiting and other symptoms, when the inflammation is eliminated, the nodules will naturally shrink and return to normal. When the inflammation is eliminated, the nodules will shrink naturally and return to normal. If it is diagnosed as inflammatory reaction, cephalosporin, cefazolin and other medicines should be taken orally for anti-inflammation in strict compliance with the doctor’s prescription. 2. Tumor: including benign and malignant tumors. Benign tumors are mostly pancreatic polyps, pancreatic cysts, solid pseudopapillary tumors, neuroendocrine tumors and so on, and the symptoms are not obvious. Malignant tumors mainly refer to pancreatic cancer, and patients often have symptoms such as body wasting and abdominal pain. Benign tumors should be timely surgical resection, while malignant tumors early after surgery, and then according to the individual situation to analyze whether the radiotherapy. If the diagnosis is only multiple nodules in the head of the pancreas, but the nature of the nodules is not known, puncture biopsy should be carried out for diagnosis and analysis, and then according to the diagnostic results of targeted treatment.