If jaundice does not subside in full-term jaundice, it may be related to excessive bilirubin production, impaired hepatic bilirubin metabolism, impaired excretion of bilirubin, and increased hepatic and intestinal circulation. 1. Excessive bilirubin production: Infection, hemolysis, erythrocytosis, hereditary spherocytosis, etc. may lead to increased destruction of red blood cells and increased production of bilirubin, which may lead to full-term jaundice. 2. Impaired hepatic bilirubin metabolism: newborns with congenital hypothyroidism or asphyxia during labor may result in low uptake and binding of bilirubin by hepatocytes, leading to elevation of unconjugated bilirubin in the serum. 3. Obstruction of bilirubin excretion: newborns with hepatitis, biliary atresia and other diseases may lead to obstruction of hepatic excretion of conjugated bilirubin or obstruction of the bile ducts, which may lead to jaundice that does not subside. 4. Increased enterohepatic circulation: Congenital biliary atresia, megacolon and other diseases may lead to delayed excretion of feces, which increases the amount of reabsorption of bilirubin by the body, and may also lead to jaundice not subsiding. Parents are advised to take their children to the pediatrician of the hospital as soon as possible, and cooperate with the doctor to complete the relevant examinations, clarify the cause of the disease and standardize the treatment.