The treatment of large ulcers in the stomach includes general treatment, drug treatment, surgical treatment and so on. 1. General treatment: avoid overwork and mental stress. Avoid spicy food and beverages such as strong tea and coffee. Smokers should quit smoking as much as possible. 2. Drug treatment: adopt the quadruple therapy of PPI (proton pump inhibitor) + bismuth + two antibiotics to cure Helicobacter pylori infection, such as omeprazole, bismuth pectin, amoxicillin, clarithromycin, etc.; anti-acid secretion drugs, such as omeprazole; gastric mucous membrane protection drugs, such as bismuth potassium citrate. Those who take aspirin should decide whether to stop taking it according to the relevant conditions. 3. Surgery: When peptic ulcer is combined with perforation, scarred pyloric obstruction and malignant gastric ulcer, surgery is feasible. If you find related diseases, you should go to the hospital in time, under the guidance of the doctor for treatment, and the drugs should be used in accordance with the doctor’s instructions.