Rice-like pimples at the knee need to be treated according to the specific cause, such as keratosis pilaris, contact dermatitis, eczema, psoriasis, etc., after a clear diagnosis to take the general treatment, drugs or laser treatment. 1. Keratosis pilaris: the rice-like bumps on the knees may belong to the pimples formed by keratosis pilaris, patients can apply adapalene gel, retinoic acid cream and other drugs to improve the symptoms, and if necessary, you can choose to remove the laser. 2. contact dermatitis: knee rice-like pimples may also be due to skin contact with allergic substances, the first need to avoid the causative factors, followed by symptomatic treatment such as topical hormone ointment (mometasone furoate, hydrocortisone butyrate, etc.), itching agents such as glycerol detergent, combined with oral antihistamines such as cetirizine, hormonal drugs, such as prednisone, and so on. 3. Eczema: Eczema is a chronic inflammatory skin disease, also need to consider and allergy related, can use glycerine lotion wet compresses, relief of itching symptoms, at the same time with antihistamines, such as cetirizine, loratadine, in addition to the use of dronederma cream coating. 4. Psoriasis: Especially psoriasis of the dot-drop type can also lead to the appearance of small bumps of rice grains in the knee, accompanied by itching. At this time, you can use topical vitamin D3 derivatives such as capotriol, hormone creams such as fluticasone propionate, etc., can be combined with oral retinoids such as Avicenna capsules, immunosuppressants such as methotrexate or cyclosporine. There are many reasons for the rice-like bumps on the knee, the above drugs should be used under the guidance of a doctor, it is recommended that the patient go to the hospital in time to complete the examination, a clear diagnosis, to give targeted treatment.