Rheumatoid usually refers to rheumatoid arthritis, if the rheumatoid arthritis condition is controlled and stabilized, some patients can gradually stop using biologics. But still need to be combined with the specific conditions of the decision, can not be generalized. In the case of rheumatoid arthritis control and stabilization of the condition, can be under the guidance of the doctor to gradually reduce the amount of biologics or lengthen the dosage of drug intervals, and some patients can even be gradually discontinued. In order to control the activity of rheumatoid arthritis in complete remission or low activity, biologics need to be used for a full course of treatment; if the drug is discontinued in the middle of the course, it may affect the therapeutic effect. Discontinuation should therefore be done carefully. Rheumatoid arthritis is a chronic, systemic autoimmune disease with erosive, symmetric polyarthritis as the main clinical manifestation. The exact pathogenesis is unknown. As the disease progresses, joints may become painful, swollen and stiff, and joint deformities may occur in the late stage, which may lead to disability in severe cases. Rheumatoid arthritis patients can take glucocorticosteroids such as methylprednisolone, anti-rheumatic drugs such as methotrexate, and biologics such as adalimumab under the guidance of doctors. Antirheumatic drugs such as hydroxychloroquine can be used in combination with biological agents such as adalimumab. However, biologics can induce adverse reactions such as severe infections. When the rheumatoid arthritis has improved significantly and the condition is stabilized, it is possible to gradually reduce the dosage and discontinue the use of biologics under the guidance of the doctor. Do not stop using them without authorization, so as not to aggravate the condition.