There is no direct relationship between menopause and thyroid nodules, and thyroid nodules are generally not significantly affected. However, endocrine disorders may occur during menopause. If necessary, thyroid function tests and neck ultrasound are recommended to clarify the condition of thyroid nodules. Thyroid nodule is a limited mass in the normal thyroid tissue, most patients may have no obvious clinical manifestations, some patients may have thyroid pain, hoarseness, and swallowing disorders, dyspnea and other compression symptoms. Menopause is the permanent absence of menstruation caused by the failure of ovarian function, which occurs in every woman’s life process; menopause is not directly related to thyroid nodules, and generally does not affect thyroid nodules. However, endocrine disorders may occur during menopause, and thyroid function tests and ultrasound of the neck are recommended when necessary to clarify the condition of thyroid nodules. For patients with thyroid nodules complicated by hyperthyroidism or hypothyroidism, menopause may have an impact on thyroid function, and regular checkups are recommended. Menopausal patients diagnosed with thyroid nodules should have their nodules reviewed regularly.