High creatinine may be caused by physiological factors such as excessive exercise and excessive meat intake. It may also be caused by diseases such as glomerulonephritis and renal failure. 1. Physiological factors: Since creatinine is produced by muscle metabolism, excessive exercise will lead to the formation of too much creatinine in the body, which will make the creatinine value exceed the normal range. Secondly, if you eat too much meat, the physiological creatinine will also be elevated. 2. Glomerulonephritis: Parental genetic factors, pathogenic infections, immune function abnormalities and other reasons may induce glomerulonephritis, so that the patient’s body creatinine value increases, the patient may also appear edema, proteinuria, hematuria, hypertension and other symptoms. 3. Renal failure: Renal failure may be induced by insufficient renal blood supply, long-term renal disease, post renal obstruction, etc., which leads to the decrease of renal excretion of metabolic wastes and the increase of creatinine value. Patients may also have symptoms such as oliguria and proteinuria, and even induce diseases such as water intoxication and hyperkalemia. It is recommended that patients with high creatinine should consult regular hospitals in time, complete relevant examinations under the guidance of physicians, clarify the cause of the disease, and carry out targeted treatment.