The patient’s thighs are nodules, the common causes are mainly the following cases. 1, allergic reaction, mostly seen in patients taking a certain drug or contact with pollen, dust and other allergens after the body allergic reaction, can be manifested as multiple scattered nodules on the thighs and accompanied by local skin itching, redness and swelling and other symptoms. The patient can take oral loratadine as soon as possible, external rubbing furnace glycolic lotion and other drugs to reduce the body’s allergic reaction, so as to quickly relieve the multiple nodules in the thigh. 2, lipoma, physical obese patients due to the abnormal accumulation of fatty tissue in the thigh, can form multiple nodules in the local. Since lipomas are benign lesions, they do not have a serious impact on the normal life of patients. For larger fat nodules, surgery can be considered to remove them.3. Enlarged lymph nodes, mostly seen in patients with acute inflammatory lesions in the body, can cause enlarged lymph nodes and hyperplasia in the thigh. Through active anti-infection treatment, the inflammation in the body can be relieved more quickly and the swollen lymph nodes can be made to subside gradually.