Painful obesity disease mainly manifests as painful nodules or fat masses on top of obesity. Painful obesity is a rare autonomic nervous system disorder of unknown etiology, manifested by abnormal accumulation of subcutaneous fat in certain parts of the trunk and accompanied by spontaneous pain in that area. This disease was first described by Dercum (1892), so it is also called Dercum’s disease. How to effectively prevent obesity and painful nodules or fat masses? Treatment There is no specific treatment for this disease. Symptomatic treatment is the main treatment, such as treatment of pain, debilitation and mental symptoms. For abnormal accumulation of fat, aspiration can be used to reduce pain, or local lidocaine (lidocaine) injection or intravenous drip can be used for pain, or oral painkillers or mexiletine (slow heart rhythm) alone. Long-term pain relief has been reported in the literature for cases treated with interferon (interferon alpha-2b) in combination with chronic hepatitis C. Prognosis The disease has a chronic progression with a poor prognosis. Psychiatric symptoms often appear at a later stage, and there is a tendency to develop dementia gradually. We should be fully aware of the harmful effects of obesity on the human body, and understand the knowledge and prevention methods of obesity in infancy, adolescence, before and after pregnancy, menopause and old age. Parents should help their children to control their weight and prevent obesity in the future. Adopt a reasonable diet, to achieve the daily three meals regularly and quantitatively, scientific arrangement of daily diet, such as diet is not greasy, not sweet and not too much, it is appropriate to increase the consumption of vegetables and coarse grains, less fat, sweet and thick, more vegetarian, less snacks. Often participate in jogging, hiking, playing ball and other outdoor activities, not only to enhance physical fitness, make the body fit, but also to prevent the occurrence of obesity. People who lose weight should pay attention to the speed of weight loss: mildly obese people can lose 0.5-1.0kg per month, moderately obese people can lose 0.5-1.0kg per week.