Hiccups in liver cancer patients indicate that there may be gastrointestinal tract dysfunction, accumulation of fluid in the chest and abdominal cavity, or cancer invading the diaphragm. 1. Insufficient power of gastrointestinal tract itself, poor digestive function, or weakened function or other disorders affected by cancer can cause hiccup symptoms. 2. Fluid accumulation in chest and abdominal cavity due to edema, poor venous return, hypoproteinemia, etc. may force gas to go upward and trigger hiccups. 3. In advanced stage of hepatocellular carcinoma, it is necessary to consider that the tumor invades the diaphragm, causing phrenic nerve involvement, which may lead to spasm of diaphragm and hiccups. Generally speaking, atropine, metoclopramide or valium should be injected, liver function should be checked, plasma or albumin should be infused intravenously according to the result, diuretics or puncture drainage should be applied appropriately, chemotherapy should be given, etc. All the above cases need timely medical treatment and chemotherapy. All of the above cases require prompt medical attention and symptomatic treatment to relieve symptoms and improve quality of life.