Premature ovarian failure, i.e. early onset ovarian insufficiency, can be treated with estrogen, progesterone, estrogen-progestogen compound preparation and other medications as prescribed by the doctor, such as estradiol valerate tablets, progesterone capsules, estradiol-dydroxyprogesterone compound tablets and so on. 1. Estrogen: Patients with early-onset ovarian insufficiency may have hot flashes, and they can follow the doctor’s instructions to use estrogenic drugs such as estradiol valerate tablets and 17-beta estradiol tablets. Patients who are sexually active can also use estradiol gel, estradiol hemihydrate patch and other topical estrogen drugs. 2. Progesterone: patients with early-onset ovarian insufficiency may have symptoms of menstrual disorders and amenorrhea, and may use progesterone capsules, micronized progesterone pills and other progesterone medications as prescribed by the doctor. 3. Estrogen-progestin compound preparation: patients with early-onset ovarian insufficiency can also follow the doctor’s instructions to use estradiol dextroprogesterone compound tablets, estradiol cyproterone tablets and other estrogen-progestin compound preparations. Patients with early-onset ovarian insufficiency should consult a doctor for timely examination and follow the doctor’s instructions to avoid blind use of medication.