There are many reasons for waking up from sleep with urine, generally considered to be caused by physiological reasons (drinking too much water before going to bed), pathological reasons (prostatitis, urinary tract infection, overactive bladder, etc.). It is necessary for the physician to take appropriate treatment measures and methods according to the different causes of the patient. 1. Physiological reasons. Drinking too much water before going to bed: when the human body before going to bed if you drink too much water, can be caused by water diuresis, at this time can be shown to sleep always woke up by the urine, belongs to the normal physiological phenomenon. 2. Pathological reasons. (1) prostatitis: due to repeated congestion of the prostate gland or due to inflammation caused by infection, can be manifested as frequent urination at night, accompanied by urinary diversion, waiting for urine, abdominal distension and other symptoms. (2) Urinary tract infections: mostly caused by cystitis or urethritis, due to unclean sex or not paying attention to personal hygiene. It can be manifested as frequent urination, urinary urgency, urinary pain, blood in urine and other manifestations. (3) Overactive bladder: frequent contraction of the urethral muscle due to overactive bladder, resulting in urinary irritation. Need to go to the hospital, a clear diagnosis of the cause of the targeted treatment, you can not just randomly use drugs.