Necrotizing granuloma generally refers to necrotizing granulomatous vasculitis, an unexplained systemic vasculitic disease. Necrotizing granulomatous vasculitis can occur at any age and is common in adults. The disease can involve many organs throughout the body, such as the nose, sinuses, eyes, ears, salivary glands, oral cavity, lungs, kidneys, joints, skin, mammary glands, mediastinum, gastrointestinal tract, pancreas, uterus, vagina, heart, spleen, periphery, and central nervous system. The upper respiratory tract, lungs and kidneys are most often involved. The disease may present differently depending on the site of involvement, with pulmonary involvement accounting for about 45% of cases, and clinical manifestations include cough, shortness of breath, coughing up blood and chest pain. Treatment is determined by the severity of the disease and the extent of organ involvement, with glucocorticoids plus cyclophosphamide being the preferred treatment for patients with renal involvement and severe respiratory disease. If you have necrotizing granulomatous vasculitis, you should seek medical attention as soon as possible, improve your examination, and follow your doctor’s instructions.