Biological agents are very effective in the treatment of rheumatoid arthritis, and can be considered in the following two cases: First, the application of traditional oral anti-rheumatic drugs is not effective, such as the use of methotrexate pteridine and combined with other anti-rheumatic drugs to treat rheumatoid arthritis for more than 3 months, the patient’s disease activity is still not controlled, still in moderate activity, then you can switch to the use of biological agents for treatment . Second, patients who have just started to diagnose rheumatoid arthritis, if the disease activity is very obvious and there are indications of poorer prognosis, such as young women with positive anti-CCP antibodies who have developed bone erosion, is also an indication for the application of biological agents. Commonly used biologic agents include Iceptab, adalimumab, infliximab, etc.