Taking off the ventilator mainly refers to the withdrawal of tracheal intubation and invasive ventilator-assisted breathing, while non-invasive ventilators can be directly and gradually discontinued after their underlying diseases and respiratory failure are stabilized. The conditions for withdrawal of invasive ventilator are clinical stability and improvement, including basic improvement of the cause of respiratory failure, control of pulmonary infection, stable vital signs, clear consciousness, and the ability to cough and cough sputum on their own with reduced sputum volume. The patient’s respiratory movement is strong and stable, and the nutritional status is improved, and the functions of all organs, including heart, liver, kidney, gastrointestinal and other functions, are stable. The psychological preparation of the patient is also important to avoid the patient’s fear that may cause difficulties in getting off the ventilator, and the patient can be taken off the ventilator if he/she can complete the spontaneous breathing test, i.e. the off-ramp test.